Tiffany Isaacs was raised in Palm Beach, Florida and resided locally until leaving to attend Emory University. After that, she lived in New York City, Miami, and London. In 2015, she moved back to the Southend with her husband, Simon Isaacs (Simon Isaacs Real Estate), and her three children. 

Isaacs is currently the CEO of LANA MARKS, an international fashion brand. Prior to this, she worked as a fashion buyer at Ralph Lauren, Saks Fifth Avenue, Net-a-Porter, and Selfridges. She is actively involved in the community and various local and international charities. A strong drive to get more involved and affect change locally, led her to join the board of SENA.